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KMID : 0370219970410030321
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Yakhak Hoeji
1997 Volume.41 No. 3 p.321 ~ p.327
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Effects of Crystal Modification of Cephalothin Sodium on Dissolution and Stability
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손영택/Sohn YT
박선희/Park SH
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Abstract
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Investigation of polymorphism has become a requirement in the pharmaceutical industry because the physical properties and bioavailabilities of crystalline drugs depend on their polymorphic form. Five polymorphic modifications and one pseudopolymorphic modification of ecphalothin sodium were prepared by recrystallization, and characterized by UV spectrophotometer, DSC, TGA and X-ray crystallography. The solubilities of all modifications were examined by the disslution test. Form 2 and 1 showed higher solubilities than any other crystal forms. The modifications were also investigated for their stability after storage of 2 months at 100%, 76%, 52% and 0% humidity.
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